Stereoselective, nitro-Mannich/lactamisation cascades for the direct synthesis of heavily decorated 5-nitropiperidin-2-ones and related heterocycles
نویسندگان
چکیده
A versatile nitro-Mannich/lactamisation cascade for the direct stereoselective synthesis of heavily decorated 5-nitropiperidin-2-ones and related heterocycles has been developed. A highly enantioenriched substituted 5-nitropiperidin-2-one was synthesised in a four component one-pot reaction combining an enantioselective organocatalytic Michael addition with the diastereoselective nitro-Mannich/lactamisation cascade. Protodenitration and chemoselective reductive manipulation of the heterocycles was used to install contiguous and fully substituted stereocentres in the synthesis of substituted piperidines.
منابع مشابه
Stereoselective Synthesis of Pyrrolidinones via Nitro-Mannich Reaction Towards the Synthesis of Popolohuanone E
3 Acknowledgements 5 Abbreviations 6 Part 1: Stereoselective Synthesis of Pyrrolidinones via Nitro-Mannich Reaction
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